Our Research

Recent Publications

  • Lee, Sungsoo S., Timmy Fyrner, Feng Chen, Zaida Álvarez, Eduard Sleep, Danielle S. Chun, Joseph A. Weiner, et al. 2017. “Sulfated glycopeptide nanostructures for multipotent protein activation”. Nature, 821–829.

    This study, performed in collaboration with the Stupp Group, describes the development of a glycosylated peptide amphiphile which self-assembles into nanofibers that mimic heparan sulfate in their capacity to bind and biomimetically present pro-osteogenic growth factors. We show here that this novel nanofiber can potentiate the osteoinductive activity of bone morphogenetic protein-2 to more efficiently promote bone regeneration and spine fusion

  • Yun, Chawon, Karina M. Katchko, Michael S. Schallmo, Soyeon Jeong, Jonghwa Yun, Charlotte H. Chen, Joseph A. Weiner, et al. 2018. “Aryl Hydrocarbon Receptor Antagonists Mitigate the Effects of Dioxin on Critical Cellular Functions in Differentiating Human Osteoblast-Like Cells”. Journal.

    This publication describes the adverse effects of dioxin on the capacity for human pre-osteoblasts to differentiate into functional osteoblasts. We explore the notion of using phytochemical-based antagonists of the aryl hydrocarbon receptor—such as resveratrol, found in red wine, and di-indolylmethane, found in cruciferous vegetables—to mitigate the adversebrought about by this major human toxicant

  • Driscoll, Adam, Ryan Lubbe, Adam E. Jakus, Kevin Chang, Meraaj Haleem, Chawon Yun, Gurmit Singh, et al. 2020. 3D-printed Ceramic-Demineralized Bone Matrix Hyperelastic Bone Composite Scaffolds for Spinal Fusion. Publisher’s Name.

    In this study, we describe for the first time a novel composite material made of hydroxyapatiteceramic and demineralized bone particles from human cadaveric bone. The material is 3D-printed into scaffolds for the purpose of regenerating new bone, and we discovered a previouslyunknown phenomenon whereby the human bone particles become re-mineralized when in close local proximity to the synthetic hydroxyapatite ceramic.