This publication describes the adverse effects of dioxin on the capacity for human pre-osteoblasts to differentiate into functional osteoblasts. We explore the notion of using phytochemical-based antagonists of the aryl hydrocarbon receptor—such as resveratrol, found in red wine, and di-indolylmethane, found in cruciferous vegetables—to mitigate the adversebrought about by this major human toxicant